crf r1 agonist stressin Search Results


crf r1 agonist 176  (Tocris)
96
Tocris crf r1 agonist 176
Crf R1 Agonist 176, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/crf+r1+agonist+stressin/10__1530_slash_joe___13___0422-80-5-9?v=Tocris
Average 96 stars, based on 1 article reviews
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hormone receptor 1 crhr1  (Proteintech)
92
Proteintech hormone receptor 1 crhr1
Changes in the behavior and protein expression in maternal separation and socially isolated mice. A: Description of the mouse behavior experiment method. Mouse behavioral experiments were conducted at week 7. B-E: There was no difference in the OFT between the CTL and the MS. In EPM to measure anxiety-like behavior, the time spent in the open arm increased in the MS compared to CTL. Considering fear-related behavior, the MS showed increased freezing in the contextual fear test compared to the CTL (N=11 mice [CTL], 8 [MS], Student’s t-test, *p<0.05). F: Compared to the CTL, the MS+SS showed significant increase in the <t>CRHR1</t> and CRHR2, which are related to stress and hypothalamic-pituitary-adrenal axis. Moreover, neurogenesis-related SOX2 and DCX demonstrated an increase in the social isolation group (CTL+SS). TrKB did not show a difference between the groups. In the t-test, CRHR1 increased in the MS and CTL+SS, and DCX increased in the CTL+SS group. It was standardized based on the protein expression ratio of the hippocampi of the control mice group (N=9 mice [CTL], 9 [CTL+SS], 9 [MS], 9 [MS+SS]; one-way analysis of variance,*p<0.05; **p<0.01, post-hoc Tukey; Student’s t-test, † p<0.05). G: Representative images of immunoblots in the mouse hippocampus. OFT, locomotion; CTL, control group; MS, maternal separation group; SS, social isolation after maternal separation group; EPM, elevated-plus maze; CRHR1, corticotropin-releasing hormone receptor 1; CRHR2, corticotropin- releasing hormone receptor 2; TrKB, tropomyosin receptor kinase B (mouse); SOX2, SRY (sex-determining region Y)-box 2; DCX, doublecortin.
Hormone Receptor 1 Crhr1, supplied by Proteintech, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/crf+r1+agonist+stressin/pmc11704808-89-34-62?v=Proteintech
Average 92 stars, based on 1 article reviews
hormone receptor 1 crhr1 - by Bioz Stars, 2026-08
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the nonspecific crf-r1/2 agonist ucn 1  (Bachem)
90
Bachem the nonspecific crf-r1/2 agonist ucn 1
Changes in the behavior and protein expression in maternal separation and socially isolated mice. A: Description of the mouse behavior experiment method. Mouse behavioral experiments were conducted at week 7. B-E: There was no difference in the OFT between the CTL and the MS. In EPM to measure anxiety-like behavior, the time spent in the open arm increased in the MS compared to CTL. Considering fear-related behavior, the MS showed increased freezing in the contextual fear test compared to the CTL (N=11 mice [CTL], 8 [MS], Student’s t-test, *p<0.05). F: Compared to the CTL, the MS+SS showed significant increase in the <t>CRHR1</t> and CRHR2, which are related to stress and hypothalamic-pituitary-adrenal axis. Moreover, neurogenesis-related SOX2 and DCX demonstrated an increase in the social isolation group (CTL+SS). TrKB did not show a difference between the groups. In the t-test, CRHR1 increased in the MS and CTL+SS, and DCX increased in the CTL+SS group. It was standardized based on the protein expression ratio of the hippocampi of the control mice group (N=9 mice [CTL], 9 [CTL+SS], 9 [MS], 9 [MS+SS]; one-way analysis of variance,*p<0.05; **p<0.01, post-hoc Tukey; Student’s t-test, † p<0.05). G: Representative images of immunoblots in the mouse hippocampus. OFT, locomotion; CTL, control group; MS, maternal separation group; SS, social isolation after maternal separation group; EPM, elevated-plus maze; CRHR1, corticotropin-releasing hormone receptor 1; CRHR2, corticotropin- releasing hormone receptor 2; TrKB, tropomyosin receptor kinase B (mouse); SOX2, SRY (sex-determining region Y)-box 2; DCX, doublecortin.
The Nonspecific Crf R1/2 Agonist Ucn 1, supplied by Bachem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
the nonspecific crf-r1/2 agonist ucn 1 - by Bioz Stars, 2026-08
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ucn 1  (Bachem)
90
Bachem ucn 1
Changes in the behavior and protein expression in maternal separation and socially isolated mice. A: Description of the mouse behavior experiment method. Mouse behavioral experiments were conducted at week 7. B-E: There was no difference in the OFT between the CTL and the MS. In EPM to measure anxiety-like behavior, the time spent in the open arm increased in the MS compared to CTL. Considering fear-related behavior, the MS showed increased freezing in the contextual fear test compared to the CTL (N=11 mice [CTL], 8 [MS], Student’s t-test, *p<0.05). F: Compared to the CTL, the MS+SS showed significant increase in the <t>CRHR1</t> and CRHR2, which are related to stress and hypothalamic-pituitary-adrenal axis. Moreover, neurogenesis-related SOX2 and DCX demonstrated an increase in the social isolation group (CTL+SS). TrKB did not show a difference between the groups. In the t-test, CRHR1 increased in the MS and CTL+SS, and DCX increased in the CTL+SS group. It was standardized based on the protein expression ratio of the hippocampi of the control mice group (N=9 mice [CTL], 9 [CTL+SS], 9 [MS], 9 [MS+SS]; one-way analysis of variance,*p<0.05; **p<0.01, post-hoc Tukey; Student’s t-test, † p<0.05). G: Representative images of immunoblots in the mouse hippocampus. OFT, locomotion; CTL, control group; MS, maternal separation group; SS, social isolation after maternal separation group; EPM, elevated-plus maze; CRHR1, corticotropin-releasing hormone receptor 1; CRHR2, corticotropin- releasing hormone receptor 2; TrKB, tropomyosin receptor kinase B (mouse); SOX2, SRY (sex-determining region Y)-box 2; DCX, doublecortin.
Ucn 1, supplied by Bachem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/crf+r1+agonist+stressin/10__1523_slash_jneurosci__4220___13__2014-102-39-46?v=Bachem
Average 90 stars, based on 1 article reviews
ucn 1 - by Bioz Stars, 2026-08
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r 2 oet oet oet  (Arkat USA Inc)
90
Arkat USA Inc r 2 oet oet oet
Changes in the behavior and protein expression in maternal separation and socially isolated mice. A: Description of the mouse behavior experiment method. Mouse behavioral experiments were conducted at week 7. B-E: There was no difference in the OFT between the CTL and the MS. In EPM to measure anxiety-like behavior, the time spent in the open arm increased in the MS compared to CTL. Considering fear-related behavior, the MS showed increased freezing in the contextual fear test compared to the CTL (N=11 mice [CTL], 8 [MS], Student’s t-test, *p<0.05). F: Compared to the CTL, the MS+SS showed significant increase in the <t>CRHR1</t> and CRHR2, which are related to stress and hypothalamic-pituitary-adrenal axis. Moreover, neurogenesis-related SOX2 and DCX demonstrated an increase in the social isolation group (CTL+SS). TrKB did not show a difference between the groups. In the t-test, CRHR1 increased in the MS and CTL+SS, and DCX increased in the CTL+SS group. It was standardized based on the protein expression ratio of the hippocampi of the control mice group (N=9 mice [CTL], 9 [CTL+SS], 9 [MS], 9 [MS+SS]; one-way analysis of variance,*p<0.05; **p<0.01, post-hoc Tukey; Student’s t-test, † p<0.05). G: Representative images of immunoblots in the mouse hippocampus. OFT, locomotion; CTL, control group; MS, maternal separation group; SS, social isolation after maternal separation group; EPM, elevated-plus maze; CRHR1, corticotropin-releasing hormone receptor 1; CRHR2, corticotropin- releasing hormone receptor 2; TrKB, tropomyosin receptor kinase B (mouse); SOX2, SRY (sex-determining region Y)-box 2; DCX, doublecortin.
R 2 Oet Oet Oet, supplied by Arkat USA Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
r 2 oet oet oet - by Bioz Stars, 2026-08
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vsense_amp  (VSense Inc)
90
VSense Inc vsense_amp
Changes in the behavior and protein expression in maternal separation and socially isolated mice. A: Description of the mouse behavior experiment method. Mouse behavioral experiments were conducted at week 7. B-E: There was no difference in the OFT between the CTL and the MS. In EPM to measure anxiety-like behavior, the time spent in the open arm increased in the MS compared to CTL. Considering fear-related behavior, the MS showed increased freezing in the contextual fear test compared to the CTL (N=11 mice [CTL], 8 [MS], Student’s t-test, *p<0.05). F: Compared to the CTL, the MS+SS showed significant increase in the <t>CRHR1</t> and CRHR2, which are related to stress and hypothalamic-pituitary-adrenal axis. Moreover, neurogenesis-related SOX2 and DCX demonstrated an increase in the social isolation group (CTL+SS). TrKB did not show a difference between the groups. In the t-test, CRHR1 increased in the MS and CTL+SS, and DCX increased in the CTL+SS group. It was standardized based on the protein expression ratio of the hippocampi of the control mice group (N=9 mice [CTL], 9 [CTL+SS], 9 [MS], 9 [MS+SS]; one-way analysis of variance,*p<0.05; **p<0.01, post-hoc Tukey; Student’s t-test, † p<0.05). G: Representative images of immunoblots in the mouse hippocampus. OFT, locomotion; CTL, control group; MS, maternal separation group; SS, social isolation after maternal separation group; EPM, elevated-plus maze; CRHR1, corticotropin-releasing hormone receptor 1; CRHR2, corticotropin- releasing hormone receptor 2; TrKB, tropomyosin receptor kinase B (mouse); SOX2, SRY (sex-determining region Y)-box 2; DCX, doublecortin.
Vsense Amp, supplied by VSense Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
vsense_amp - by Bioz Stars, 2026-08
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total r 1  (Santa Cruz Biotechnology)
93
Santa Cruz Biotechnology total r 1
Changes in the behavior and protein expression in maternal separation and socially isolated mice. A: Description of the mouse behavior experiment method. Mouse behavioral experiments were conducted at week 7. B-E: There was no difference in the OFT between the CTL and the MS. In EPM to measure anxiety-like behavior, the time spent in the open arm increased in the MS compared to CTL. Considering fear-related behavior, the MS showed increased freezing in the contextual fear test compared to the CTL (N=11 mice [CTL], 8 [MS], Student’s t-test, *p<0.05). F: Compared to the CTL, the MS+SS showed significant increase in the <t>CRHR1</t> and CRHR2, which are related to stress and hypothalamic-pituitary-adrenal axis. Moreover, neurogenesis-related SOX2 and DCX demonstrated an increase in the social isolation group (CTL+SS). TrKB did not show a difference between the groups. In the t-test, CRHR1 increased in the MS and CTL+SS, and DCX increased in the CTL+SS group. It was standardized based on the protein expression ratio of the hippocampi of the control mice group (N=9 mice [CTL], 9 [CTL+SS], 9 [MS], 9 [MS+SS]; one-way analysis of variance,*p<0.05; **p<0.01, post-hoc Tukey; Student’s t-test, † p<0.05). G: Representative images of immunoblots in the mouse hippocampus. OFT, locomotion; CTL, control group; MS, maternal separation group; SS, social isolation after maternal separation group; EPM, elevated-plus maze; CRHR1, corticotropin-releasing hormone receptor 1; CRHR2, corticotropin- releasing hormone receptor 2; TrKB, tropomyosin receptor kinase B (mouse); SOX2, SRY (sex-determining region Y)-box 2; DCX, doublecortin.
Total R 1, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
total r 1 - by Bioz Stars, 2026-08
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transcript variant 1  (OriGene)
90
OriGene transcript variant 1
Changes in the behavior and protein expression in maternal separation and socially isolated mice. A: Description of the mouse behavior experiment method. Mouse behavioral experiments were conducted at week 7. B-E: There was no difference in the OFT between the CTL and the MS. In EPM to measure anxiety-like behavior, the time spent in the open arm increased in the MS compared to CTL. Considering fear-related behavior, the MS showed increased freezing in the contextual fear test compared to the CTL (N=11 mice [CTL], 8 [MS], Student’s t-test, *p<0.05). F: Compared to the CTL, the MS+SS showed significant increase in the <t>CRHR1</t> and CRHR2, which are related to stress and hypothalamic-pituitary-adrenal axis. Moreover, neurogenesis-related SOX2 and DCX demonstrated an increase in the social isolation group (CTL+SS). TrKB did not show a difference between the groups. In the t-test, CRHR1 increased in the MS and CTL+SS, and DCX increased in the CTL+SS group. It was standardized based on the protein expression ratio of the hippocampi of the control mice group (N=9 mice [CTL], 9 [CTL+SS], 9 [MS], 9 [MS+SS]; one-way analysis of variance,*p<0.05; **p<0.01, post-hoc Tukey; Student’s t-test, † p<0.05). G: Representative images of immunoblots in the mouse hippocampus. OFT, locomotion; CTL, control group; MS, maternal separation group; SS, social isolation after maternal separation group; EPM, elevated-plus maze; CRHR1, corticotropin-releasing hormone receptor 1; CRHR2, corticotropin- releasing hormone receptor 2; TrKB, tropomyosin receptor kinase B (mouse); SOX2, SRY (sex-determining region Y)-box 2; DCX, doublecortin.
Transcript Variant 1, supplied by OriGene, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
transcript variant 1 - by Bioz Stars, 2026-08
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tnf r 1  (Santa Cruz Biotechnology)
94
Santa Cruz Biotechnology tnf r 1
Changes in the behavior and protein expression in maternal separation and socially isolated mice. A: Description of the mouse behavior experiment method. Mouse behavioral experiments were conducted at week 7. B-E: There was no difference in the OFT between the CTL and the MS. In EPM to measure anxiety-like behavior, the time spent in the open arm increased in the MS compared to CTL. Considering fear-related behavior, the MS showed increased freezing in the contextual fear test compared to the CTL (N=11 mice [CTL], 8 [MS], Student’s t-test, *p<0.05). F: Compared to the CTL, the MS+SS showed significant increase in the <t>CRHR1</t> and CRHR2, which are related to stress and hypothalamic-pituitary-adrenal axis. Moreover, neurogenesis-related SOX2 and DCX demonstrated an increase in the social isolation group (CTL+SS). TrKB did not show a difference between the groups. In the t-test, CRHR1 increased in the MS and CTL+SS, and DCX increased in the CTL+SS group. It was standardized based on the protein expression ratio of the hippocampi of the control mice group (N=9 mice [CTL], 9 [CTL+SS], 9 [MS], 9 [MS+SS]; one-way analysis of variance,*p<0.05; **p<0.01, post-hoc Tukey; Student’s t-test, † p<0.05). G: Representative images of immunoblots in the mouse hippocampus. OFT, locomotion; CTL, control group; MS, maternal separation group; SS, social isolation after maternal separation group; EPM, elevated-plus maze; CRHR1, corticotropin-releasing hormone receptor 1; CRHR2, corticotropin- releasing hormone receptor 2; TrKB, tropomyosin receptor kinase B (mouse); SOX2, SRY (sex-determining region Y)-box 2; DCX, doublecortin.
Tnf R 1, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 94 stars, based on 1 article reviews
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separate window r 1  (ATCC)
96
ATCC separate window r 1
MIC (μg/mL), in vitro cytotoxicity, and kidney exposure of compounds of general structure (Va) n=1 showing the importance of position of the amino group on the N-terminal chain
Separate Window R 1, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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separate window r 1 - by Bioz Stars, 2026-08
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pgl3-plagl1p-r1  (Promega)
90
Promega pgl3-plagl1p-r1
MIC (μg/mL), in vitro cytotoxicity, and kidney exposure of compounds of general structure (Va) n=1 showing the importance of position of the amino group on the N-terminal chain
Pgl3 Plagl1p R1, supplied by Promega, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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skydio r1  (Skydio Inc)
90
Skydio Inc skydio r1
MIC (μg/mL), in vitro cytotoxicity, and kidney exposure of compounds of general structure (Va) n=1 showing the importance of position of the amino group on the N-terminal chain
Skydio R1, supplied by Skydio Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Changes in the behavior and protein expression in maternal separation and socially isolated mice. A: Description of the mouse behavior experiment method. Mouse behavioral experiments were conducted at week 7. B-E: There was no difference in the OFT between the CTL and the MS. In EPM to measure anxiety-like behavior, the time spent in the open arm increased in the MS compared to CTL. Considering fear-related behavior, the MS showed increased freezing in the contextual fear test compared to the CTL (N=11 mice [CTL], 8 [MS], Student’s t-test, *p<0.05). F: Compared to the CTL, the MS+SS showed significant increase in the CRHR1 and CRHR2, which are related to stress and hypothalamic-pituitary-adrenal axis. Moreover, neurogenesis-related SOX2 and DCX demonstrated an increase in the social isolation group (CTL+SS). TrKB did not show a difference between the groups. In the t-test, CRHR1 increased in the MS and CTL+SS, and DCX increased in the CTL+SS group. It was standardized based on the protein expression ratio of the hippocampi of the control mice group (N=9 mice [CTL], 9 [CTL+SS], 9 [MS], 9 [MS+SS]; one-way analysis of variance,*p<0.05; **p<0.01, post-hoc Tukey; Student’s t-test, † p<0.05). G: Representative images of immunoblots in the mouse hippocampus. OFT, locomotion; CTL, control group; MS, maternal separation group; SS, social isolation after maternal separation group; EPM, elevated-plus maze; CRHR1, corticotropin-releasing hormone receptor 1; CRHR2, corticotropin- releasing hormone receptor 2; TrKB, tropomyosin receptor kinase B (mouse); SOX2, SRY (sex-determining region Y)-box 2; DCX, doublecortin.

Journal: Psychiatry Investigation

Article Title: Translational Approach to Social Isolation During a Global Pandemic: Hippocampal Somatic Mutation and Stress

doi: 10.30773/pi.2024.0178

Figure Lengend Snippet: Changes in the behavior and protein expression in maternal separation and socially isolated mice. A: Description of the mouse behavior experiment method. Mouse behavioral experiments were conducted at week 7. B-E: There was no difference in the OFT between the CTL and the MS. In EPM to measure anxiety-like behavior, the time spent in the open arm increased in the MS compared to CTL. Considering fear-related behavior, the MS showed increased freezing in the contextual fear test compared to the CTL (N=11 mice [CTL], 8 [MS], Student’s t-test, *p<0.05). F: Compared to the CTL, the MS+SS showed significant increase in the CRHR1 and CRHR2, which are related to stress and hypothalamic-pituitary-adrenal axis. Moreover, neurogenesis-related SOX2 and DCX demonstrated an increase in the social isolation group (CTL+SS). TrKB did not show a difference between the groups. In the t-test, CRHR1 increased in the MS and CTL+SS, and DCX increased in the CTL+SS group. It was standardized based on the protein expression ratio of the hippocampi of the control mice group (N=9 mice [CTL], 9 [CTL+SS], 9 [MS], 9 [MS+SS]; one-way analysis of variance,*p<0.05; **p<0.01, post-hoc Tukey; Student’s t-test, † p<0.05). G: Representative images of immunoblots in the mouse hippocampus. OFT, locomotion; CTL, control group; MS, maternal separation group; SS, social isolation after maternal separation group; EPM, elevated-plus maze; CRHR1, corticotropin-releasing hormone receptor 1; CRHR2, corticotropin- releasing hormone receptor 2; TrKB, tropomyosin receptor kinase B (mouse); SOX2, SRY (sex-determining region Y)-box 2; DCX, doublecortin.

Article Snippet: The cell lysates (20 μg) were electrophoresis using SDS gels and transferred to nitrocellulose membranes and the incubated with tropomyosin receptor kinase B (TrkB) antibody (1:1,000, goat, AF1494; R&D systems, Minneapolis, MN, USA), corticotropin-releasing hormone receptor 1 (CRHR1) antibody (1:1,000, goat, GRX88961; GeneTex, Irvine, CA, USA), CRHR2 antibody (1:1,000, rabbit, AP17244PU-N; OriGene Technologies Inc., Rockville, MD, USA), Grin2B antibody (1:1,000, rabbit, 21920-1-AP; Proteintech, Rosemont, IL, USA), HTR1B antibody (1:1,000, rabbit, OAAF02797; Aviva Systems Biology, San Diego, CA, USA), doublecortin (DCX) antibody (1:1,000, rabbit, #4604; Cell Signaling Technology, Danvers, MA, USA), MAP2 antibody (1:1,000, rabbit, #4542; Cell Signaling Technology), SOX2 antibody (1:1,000, rabbit, #23064; Cell Signaling Technology), NeuN antibody (1:1,000, rabbit, #24307; Cell Signaling Technology), Erk antibody (1:1,000, rabbit, #4695; Cell Signaling Technology), p-Erk (thy202/204) antibody (1:1,000, rabbit, #9101; Cell Signaling Technology), mTOR antibody (1:1,000, rabbit, #2983; Cell Signaling Technology), p-mTOR antibody (1:1,000, rabbit, #5536; Cell Signaling Technology) and β-actin antibody (1:10,000, mouse, Sc-47778 HRP; Santa Cruz Biotechnology, Dallas, TX, USA) for 16 hours at 4°C.

Techniques: Expressing, Isolation, Control, Western Blot

MIC (μg/mL), in vitro cytotoxicity, and kidney exposure of compounds of general structure (Va) n=1 showing the importance of position of the amino group on the N-terminal chain

Journal: ACS infectious diseases

Article Title: Design of Next Generation Polymyxins with Lower Toxicity: The Discovery of SPR206

doi: 10.1021/acsinfecdis.9b00217

Figure Lengend Snippet: MIC (μg/mL), in vitro cytotoxicity, and kidney exposure of compounds of general structure (Va) n=1 showing the importance of position of the amino group on the N-terminal chain

Article Snippet: 14 The importance of the amino acid as position 1 for activity (and toxicity) was at this stage not clearly defined and it was an early target for us to understand this relationship further. table ft1 table-wrap mode="anchored" t5 Table 1. caption a7 Open in a separate window R 1 C(O)- diastereomer a E.coli IHMA 558090 E. coli ATCC 25922 K. pneumoniae ATCC 4352 P. aeruginosa ATCC 27853 A. baumannii NCTC13424 Cytotoxicity (HK-2 IC 50 rel to PMB) 4h kidney level ( μ g/g) Kidney AUC 4-16 ( μ g.h/g) 1a Open in a separate window - 4 0.25 0.125 0.5 0.25 1 126 688 2 Open in a separate window - 16 0.5 0.5 0.5 4 3.0 110 574 3 Open in a separate window - ND 0.25 0.25 0.5 1 ND ND ND 4 Open in a separate window - ND 8 8 1 >8 ND ND ND 5 Open in a separate window - ND 4 4 1 4 ND ND ND 6 Open in a separate window D1 16 0.125 0.06 0.25 0.25 ND ND ND 7 D2 2 0.06 0.06 0.125 0.25 1.1 212 982 8 Open in a separate window D1 16 0.125 ND 0.125 0.06 ND 242 ND 9 D2 8 0.125 ND 0.125 0.125 ND ND ND 10 Open in a separate window D1 64 2 0.5 0.5 >8 ND ND ND 11 D2 2 0.125 0.06 0.125 0.125 4.2 289 3320 12 Open in a separate window - ND 0.5 0.5 0.5 2 ND ND ND 13 Open in a separate window - ND >8 >8 4 >8 ND ND ND Open in a separate window ND=not determined. a Where compounds were prepared from racemic starting material at the acyl terminus, the resulting diastereomers are denoted D1 or D2 referring to faster-eluting and slower-eluting diastereomers by reverse-phase HPLC respectively.

Techniques: In Vitro